Follow the below steps to Remove Issue From Epic
Method 1: Single Edit
Select the Story > Click on the Epic Link field > Remove Epic link by clicking on the ‘x‘ sign on it

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Method 2: Bulk Edit
Click on the Epic Link (to see multiple stories related story to this epic) > Click on three dots (above the story) > Select ‘Bulk edit‘ (from the list) > Select ‘Edit Issues‘ > Choose ‘Change Epic Link‘ > Keep the Change Epic Link Field Empty > Click on ‘Confirm‘ button